De novo assembly of ancient metagenomes to reconstruct biosynthetic machinery and access Pleistocene bacterial metabolites. This repository belongs to the following publication (DOI: 10.1126/science.adf5300):

Klapper, M., Hübner, A., Ibrahim A. et al. "Natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic". Science 380, 619–624 (2023).

Additional code, data, and figures to complement the supplementary information of the study can be found in:

• 01-ressources contains the basic information to reproduce the results of this study.

• 02-scripts contains all the scripts and Jupyter notebooks to prepare and analyse the data.

• 05-results contains the results of the analyses that are used to produce the figures and tables presented in the manuscript.

• 06-figures_tables contains the final figures and tables presented in the study.

A compressed version of this repository together with huge NMR and GCMS data has been deposited in this long-term Zenodo archive: https://zenodo.org/records/7244132 (1.3 GB)