n+1 runs about drop HOT 2 CLOSED

The pipeline was designed thinking about this possibility. Simply add the sample to the sample annotation file as a new row.
For the aberrant expression module, it will count only that sample, then merge, filter and run OUTRIDER in all of them. In this way you avoid counting N-1 samples.
For the aberrant splicing module, it will count the split reads of only that sample, then merge, create the junction for the non-split reads (because this sample could have added new splice sites not seen before), count the split-reads, merge, filter and run FRASER in all samples. You avoid counting the split reads of N-1 samples. Be sure to have the parameter recount=FALSE, so that it doesn't perform the split reads of the N-1 samples.
For the mae module, it will perform the allelic counts and test on this sample only. Afterwards it will merge the results.

from drop.

Ok great.

from drop.