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lh3 avatar lh3 commented on September 15, 2024

It would be good to track the source of a reference sequence. More precisely, given an officially accessioned reference sequence R and a user modified sequence U, we say U is alpha-derived from R if a) R and U are of the same length and b) the per-base sequence divergence, excluding gaps, is smaller than an arbitrary threshold alpha. Datasets/studies using sequences derived from the same accessioned reference can be queried together. This helps consistencies across multiple data sets even if they use genomes slightly modified in different ways.

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delagoya avatar delagoya commented on September 15, 2024

+1 yes I think it should be required.

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dglazer avatar dglazer commented on September 15, 2024

Closing this in favor of @richarddurbin 's concrete proposal in #66 -- let's discuss the details there.

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