i have tried this code and sent the path of a file but it only checks the string sent and not the file.

works perfectly with strings.

Here is a modification I made to turn this script into a class. It can then be placed in a Classic ASP web page and included without causing variable name clashes.

' Source http://chayoung.tistory.com/entry/VBScript-MD5
' found via http://stackoverflow.com/questions/10198690/how-to-generate-md5-using-vb-in-classic-asp/10198875#10198875

' Constants cannot be contained withing the class
Private Const BITS_TO_A_BYTE = 8
Private Const BYTES_TO_A_WORD = 4
Private Const BITS_TO_A_WORD = 32
Class MD5
Private m_lOnBits(30)
Private m_l2Power(30)

' Use Constructor to initialize arrays
Private Sub Class_Initialize()
Dim idx
For idx = 0 To 30
m_lOnBits(idx) = CLng(2 ^ (idx + 1) - 1)
m_l2Power(idx) = CLng(2 ^ idx)
Next
End Sub

Private Function LShift(lValue, iShiftBits)
If iShiftBits = 0 Then
LShift = lValue
Exit Function
ElseIf iShiftBits = 31 Then
If lValue And 1 Then
LShift = &H80000000
Else
LShift = 0
End If
Exit Function
ElseIf iShiftBits < 0 Or iShiftBits > 31 Then
Err.Raise 6
End If
If (lValue And m_l2Power(31 - iShiftBits)) Then
LShift = ((lValue And m_lOnBits(31 - (iShiftBits + 1))) * m_l2Power(iShiftBits)) Or &H80000000
Else
LShift = ((lValue And m_lOnBits(31 - iShiftBits)) * m_l2Power(iShiftBits))
End If
End Function

Private Function RShift(lValue, iShiftBits)
If iShiftBits = 0 Then
RShift = lValue
Exit Function
ElseIf iShiftBits = 31 Then
If lValue And &H80000000 Then
RShift = 1
Else
RShift = 0
End If
Exit Function
ElseIf iShiftBits < 0 Or iShiftBits > 31 Then
Err.Raise 6
End If
RShift = (lValue And &H7FFFFFFE) \ m_l2Power(iShiftBits)
If (lValue And &H80000000) Then
RShift = (RShift Or (&H40000000 \ m_l2Power(iShiftBits - 1)))
End If
End Function

Private Function RotateLeft(lValue, iShiftBits)
RotateLeft = LShift(lValue, iShiftBits) Or RShift(lValue, (32 - iShiftBits))
End Function

Private Function AddUnsigned(lX, lY)
Dim lX4
Dim lY4
Dim lX8
Dim lY8
Dim lResult
lX8 = lX And &H80000000
lY8 = lY And &H80000000
lX4 = lX And &H40000000
lY4 = lY And &H40000000
lResult = (lX And &H3FFFFFFF) + (lY And &H3FFFFFFF)
If lX4 And lY4 Then
lResult = lResult Xor &H80000000 Xor lX8 Xor lY8
ElseIf lX4 Or lY4 Then
If lResult And &H40000000 Then
lResult = lResult Xor &HC0000000 Xor lX8 Xor lY8
Else
lResult = lResult Xor &H40000000 Xor lX8 Xor lY8
End If
Else
lResult = lResult Xor lX8 Xor lY8
End If
AddUnsigned = lResult
End Function

Private Function F(x, y, z)
F = (x And y) Or ((Not x) And z)
End Function
Private Function G(x, y, z)
G = (x And z) Or (y And (Not z))
End Function
Private Function H(x, y, z)
H = (x Xor y Xor z)
End Function
Private Function I(x, y, z)
I = (y Xor (x Or (Not z)))
End Function

Private Sub FF(a, b, c, d, x, s, ac)
a = AddUnsigned(a, AddUnsigned(AddUnsigned(F(b, c, d), x), ac))
a = RotateLeft(a, s)
a = AddUnsigned(a, b)
End Sub
Private Sub GG(a, b, c, d, x, s, ac)
a = AddUnsigned(a, AddUnsigned(AddUnsigned(G(b, c, d), x), ac))
a = RotateLeft(a, s)
a = AddUnsigned(a, b)
End Sub
Private Sub HH(a, b, c, d, x, s, ac)
a = AddUnsigned(a, AddUnsigned(AddUnsigned(H(b, c, d), x), ac))
a = RotateLeft(a, s)
a = AddUnsigned(a, b)
End Sub
Private Sub II(a, b, c, d, x, s, ac)
a = AddUnsigned(a, AddUnsigned(AddUnsigned(I(b, c, d), x), ac))
a = RotateLeft(a, s)
a = AddUnsigned(a, b)
End Sub

Private Function ConvertToWordArray(sMessage)
Dim lMessageLength
Dim lNumberOfWords
Dim lWordArray()
Dim lBytePosition
Dim lByteCount
Dim lWordCount
Const MODULUS_BITS = 512
Const CONGRUENT_BITS = 448
lMessageLength = Len(sMessage)
lNumberOfWords = (((lMessageLength + ((MODULUS_BITS - CONGRUENT_BITS) \ BITS_TO_A_BYTE)) \ (MODULUS_BITS \ BITS_TO_A_BYTE)) + 1) * (MODULUS_BITS \ BITS_TO_A_WORD)
ReDim lWordArray(lNumberOfWords - 1)
lBytePosition = 0
lByteCount = 0
Do Until lByteCount >= lMessageLength
lWordCount = lByteCount \ BYTES_TO_A_WORD
lBytePosition = (lByteCount Mod BYTES_TO_A_WORD) * BITS_TO_A_BYTE
lWordArray(lWordCount) = lWordArray(lWordCount) Or LShift(Asc(Mid(sMessage, lByteCount + 1, 1)), lBytePosition)
lByteCount = lByteCount + 1
Loop
lWordCount = lByteCount \ BYTES_TO_A_WORD
lBytePosition = (lByteCount Mod BYTES_TO_A_WORD) * BITS_TO_A_BYTE
lWordArray(lWordCount) = lWordArray(lWordCount) Or LShift(&H80, lBytePosition)
lWordArray(lNumberOfWords - 2) = LShift(lMessageLength, 3)
lWordArray(lNumberOfWords - 1) = RShift(lMessageLength, 29)
ConvertToWordArray = lWordArray
End Function

Private Function WordToHex(lValue)
Dim lByte
Dim lCount
For lCount = 0 To 3
lByte = RShift(lValue, lCount * BITS_TO_A_BYTE) And m_lOnBits(BITS_TO_A_BYTE - 1)
WordToHex = WordToHex & Right("0" & Hex(lByte), 2)
Next
End Function

Public Function Hash(sMessage)
Dim x
Dim k
Dim AA
Dim BB
Dim CC
Dim DD
Dim a
Dim b
Dim c
Dim d
Const S11 = 7
Const S12 = 12
Const S13 = 17
Const S14 = 22
Const S21 = 5
Const S22 = 9
Const S23 = 14
Const S24 = 20
Const S31 = 4
Const S32 = 11
Const S33 = 16
Const S34 = 23
Const S41 = 6
Const S42 = 10
Const S43 = 15
Const S44 = 21
x = ConvertToWordArray(sMessage)
a = &H67452301
b = &HEFCDAB89
c = &H98BADCFE
d = &H10325476
For k = 0 To UBound(x) Step 16
AA = a
BB = b
CC = c
DD = d
FF a, b, c, d, x(k + 0), S11, &HD76AA478
FF d, a, b, c, x(k + 1), S12, &HE8C7B756
FF c, d, a, b, x(k + 2), S13, &H242070DB
FF b, c, d, a, x(k + 3), S14, &HC1BDCEEE
FF a, b, c, d, x(k + 4), S11, &HF57C0FAF
FF d, a, b, c, x(k + 5), S12, &H4787C62A
FF c, d, a, b, x(k + 6), S13, &HA8304613
FF b, c, d, a, x(k + 7), S14, &HFD469501
FF a, b, c, d, x(k + 8), S11, &H698098D8
FF d, a, b, c, x(k + 9), S12, &H8B44F7AF
FF c, d, a, b, x(k + 10), S13, &HFFFF5BB1
FF b, c, d, a, x(k + 11), S14, &H895CD7BE
FF a, b, c, d, x(k + 12), S11, &H6B901122
FF d, a, b, c, x(k + 13), S12, &HFD987193
FF c, d, a, b, x(k + 14), S13, &HA679438E
FF b, c, d, a, x(k + 15), S14, &H49B40821
GG a, b, c, d, x(k + 1), S21, &HF61E2562
GG d, a, b, c, x(k + 6), S22, &HC040B340
GG c, d, a, b, x(k + 11), S23, &H265E5A51
GG b, c, d, a, x(k + 0), S24, &HE9B6C7AA
GG a, b, c, d, x(k + 5), S21, &HD62F105D
GG d, a, b, c, x(k + 10), S22, &H2441453
GG c, d, a, b, x(k + 15), S23, &HD8A1E681
GG b, c, d, a, x(k + 4), S24, &HE7D3FBC8
GG a, b, c, d, x(k + 9), S21, &H21E1CDE6
GG d, a, b, c, x(k + 14), S22, &HC33707D6
GG c, d, a, b, x(k + 3), S23, &HF4D50D87
GG b, c, d, a, x(k + 8), S24, &H455A14ED
GG a, b, c, d, x(k + 13), S21, &HA9E3E905
GG d, a, b, c, x(k + 2), S22, &HFCEFA3F8
GG c, d, a, b, x(k + 7), S23, &H676F02D9
GG b, c, d, a, x(k + 12), S24, &H8D2A4C8A
HH a, b, c, d, x(k + 5), S31, &HFFFA3942
HH d, a, b, c, x(k + 8), S32, &H8771F681
HH c, d, a, b, x(k + 11), S33, &H6D9D6122
HH b, c, d, a, x(k + 14), S34, &HFDE5380C
HH a, b, c, d, x(k + 1), S31, &HA4BEEA44
HH d, a, b, c, x(k + 4), S32, &H4BDECFA9
HH c, d, a, b, x(k + 7), S33, &HF6BB4B60
HH b, c, d, a, x(k + 10), S34, &HBEBFBC70
HH a, b, c, d, x(k + 13), S31, &H289B7EC6
HH d, a, b, c, x(k + 0), S32, &HEAA127FA
HH c, d, a, b, x(k + 3), S33, &HD4EF3085
HH b, c, d, a, x(k + 6), S34, &H4881D05
HH a, b, c, d, x(k + 9), S31, &HD9D4D039
HH d, a, b, c, x(k + 12), S32, &HE6DB99E5
HH c, d, a, b, x(k + 15), S33, &H1FA27CF8
HH b, c, d, a, x(k + 2), S34, &HC4AC5665
II a, b, c, d, x(k + 0), S41, &HF4292244
II d, a, b, c, x(k + 7), S42, &H432AFF97
II c, d, a, b, x(k + 14), S43, &HAB9423A7
II b, c, d, a, x(k + 5), S44, &HFC93A039
II a, b, c, d, x(k + 12), S41, &H655B59C3
II d, a, b, c, x(k + 3), S42, &H8F0CCC92
II c, d, a, b, x(k + 10), S43, &HFFEFF47D
II b, c, d, a, x(k + 1), S44, &H85845DD1
II a, b, c, d, x(k + 8), S41, &H6FA87E4F
II d, a, b, c, x(k + 15), S42, &HFE2CE6E0
II c, d, a, b, x(k + 6), S43, &HA3014314
II b, c, d, a, x(k + 13), S44, &H4E0811A1
II a, b, c, d, x(k + 4), S41, &HF7537E82
II d, a, b, c, x(k + 11), S42, &HBD3AF235
II c, d, a, b, x(k + 2), S43, &H2AD7D2BB
II b, c, d, a, x(k + 9), S44, &HEB86D391
a = AddUnsigned(a, AA)
b = AddUnsigned(b, BB)
c = AddUnsigned(c, CC)
d = AddUnsigned(d, DD)
Next

Hash = LCase(WordToHex(a) & WordToHex(b) & WordToHex(c) & WordToHex(d))
End Function
End Class

' Test
' Set objMD5 = MD5
' WScript.Echo objMD5.Hash("Test")