Equations and tools for clinical pharmacokinetics
nca(): Non-compartmental PK analysis, e.g. AUC, half-life, etc.calc_kel_single_tdm(): calculate elimination rate (for linear 1-cmt model) based on single TDM sample and provided volume of distribution.calc_t12(): calculate effective half-life based on two TDM points.calc_amts_for_conc(): Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state.find_nearest_dose(): Find nearest available dose based on smallest available dosing unitfind_nearest_interval(): Find nearest (or nearest higher / nearest lower) dosing interval
calc_bsa(): BSA calculation using various equationscalc_ffm(): Fat-free mass using various equationscalc_bmi(): Body mass indexcalc_ibw(): Ideal body weight, using various equations for children and adultscalc_lbw(): Lean body weightcalc_abw(): Adjusted body weight (for obese patients)pct_weight_for_age(): calculate percentile of weight given age (for kids <= 10 yrs)pct_height_for_age(): calculate percentile of height given age (for kids <= 19 yrs)pct_bmi_for_age(): calculate percentile of height given age (for kids <= 19 yrs)
calc_egfr(): eGFR calculation from serum creatinine using various equations (Cockcroft-Gault, MDRD, CKD-EPI, Jelliffe, Jelliffe for unstable patients, Wright, Lund-Malmo revised, Schwartz, Schwartz revised)calc_egfr_cystatin(): eGFR calculation from Cystatin C concentrations using various equations (Grubb, Larsson)calc_creat(): mean serum creatinine for children and adults (given age and sex)calc_creat_neo(): typical serum creatinine for neonates given post-natal ageconvert_creat_assay(): convert between various creatinine assays (Jaffe, IDMS, etc)convert_creat_unit(): convert between creatinine units (mmol/L, mg/dL)
kg2lbs(): kg to poundslbs2kg(): pounds to kgweight2kg(): any weight unit to kgcm2inch(): cm to inchesinch2cm(): inches to cmconc2mol(): concentration to molarmol2conc(): molar to concentration
Functions to simulate concentrations for linear PK models.
| function | compartments | administration | type | output |
|---|---|---|---|---|
pk_1cmt_inf() |
1 | infusion | single/multi dose | concentration table |
pk_1cmt_inf_ss() |
1 | infusion | steady state | concentration table |
pk_1cmt_inf_cmin_ss() |
1 | infusion | steady state | Cmin |
pk_1cmt_inf_cmax_ss() |
1 | infusion | steady state | Cmax |
pk_2cmt_inf() |
2 | infusion | single/multi dose | concentration table |
pk_2cmt_inf_ss() |
2 | infusion | steady state | concentration table |
pk_2cmt_inf_cmin_ss() |
2 | infusion | steady state | Cmin |
pk_2cmt_inf_cmax_ss() |
2 | infusion | steady state | Cmax |
pk_1cmt_bolus() |
1 | bolus | single/multi dose | concentration table |
pk_1cmt_bolus_ss() |
1 | bolus | steady state | concentration table |
pk_1cmt_bolus_cmin_ss() |
1 | bolus | steady state | Cmin |
pk_1cmt_bolus_cmax_ss() |
1 | bolus | steady state | Cmax |
pk_1cmt_t12() |
1 | - | - | half-life |
pk_1cmt_oral() |
1 | oral | - | concentration |
pk_2cmt_bolus() |
2 | bolus | single/multi dose | concentration table |
pk_2cmt_bolus_ss() |
2 | bolus | steady state | concentration table |
pk_2cmt_bolus_cmin_ss() |
2 | bolus | steady state | Cmin |
pk_2cmt_bolus_cmax_ss() |
2 | bolus | steady state | Cmax |
pk_2cmt_t12() |
2 | - | - | terminal half-life |
pk_2cmt_t12_interval() |
2 | - | - | effective half-life in given interval |
Functions to calculate the dose expected to achieve a specific target exposure.
| function | compartments | administration | target | output |
|---|---|---|---|---|
pk_1cmt_inf_dose_for_cmin |
1 | infusion | cmin | dose |
pk_1cmt_bolus_dose_for_cmin |
1 | bolus | cmin | dose |
pk_2cmt_inf_dose_for_cmin() |
2 | infusion | cmin | dose |
pk_2cmt_bolus_dose_for_cmin() |
2 | bolus | cmin | dose |
pk_1cmt_inf_dose_for_cmax |
1 | infusion | cmax | dose |
pk_1cmt_bolus_dose_for_cmax |
1 | bolus | cmax | dose |
pk_2cmt_inf_dose_for_cmax() |
2 | infusion | cmax | dose |
pk_2cmt_bolus_dose_for_cmax() |
2 | bolus | cmax | dose |
dose2auc() |
1 | - | auc | auc |
auc2dose() |
1 | - | auc | dose |
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