shiva-kannan / msa-tool Goto Github PK

This tool is mainly to parse through an MSA file (in the MEGA format) and give out a UI representation of the analysis of the mutations occurred.

• Still in the development phases. Would be putting out a link to the binaries once the complete development and testing is done.

2 widgets:

• First (main) widget asks user to select MEGA file from desktop. It shows minimal information of how many mutations and the score.

• • The main window lets you select the MEGA file from your file browser
• • Once the file is selected it displays to you the details in the tabular form as shown.

• Second window pops up when user double clicks the residue . It shows a detailed overview of the mutations.

• • The following is an example when a residue is clicked from the first window.

• • Residue range selection: This lets you select the range of residues that you particularly want to filter out. Note: Should click the Apply Filter button for it to be effective.

• • Substitution Matrix score-threshold selection : The score as shown in the 4th column represents the cumulative summation of the scores of the mutations that have happened from the wild type. This can be filtered => 1) All scores 2) Scores < 0 3) Scores < -1
• • Double-click on the residue from the detailed window will take you to the Uniprot page of the strain.

Uniprot Query :

• Shiva Kannan [email protected]