This is the source codes of DrugComboExplorer.
Please first unzip the folders "ly3_signal_info_update_seed.zip" and "oci_ly3_group_pathway_target_effect.zip"
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Run "oci_ly3_shortest_distance_between_driver_signaling_pathways.py" to obtain the distances between driver signaling pathways of Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBCL) patients from TCGA database.
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Run "drug_combination_ranking_res_oci_ly3_pathway_target_effects_validate.py" to rank the drug combinations for DLBCL patients.
Please check the guide file: DrugComboExplorer_user_guide_v1.docx