Heart Rate Variability measurement on a single-lead raw Zio Patch ECG signal

• R-peak and Sinus Signal Detection for HRV analysis: R_peak_detector code

  Run Main.m file from R_peak_detector folder to calculate r-peaks and select a single 3-minute sinus epoch of signal. Utilizes modified pan-tompkins, principle component analysis, and parabolic fitting algorithms for r-peak detection. RR intervals considered sinus if the duration of RR-interval is within 15% of the duration of the previous RR-interval

• HRV Analysis: HRV_full code

  Run Main.m file from HRV_full folder on data after running R-peak detection code (above) Code will calculate heart rate and HRV parameters (RMSSD, LF, HF, LF/HF, SD1, SD2, SD1/SD2, Sample entropy, renyi entropy)

• Test files: 130812_Z320892913_1563

  9 hours of raw data from single lead ZioPatch

• Fully de-identified dataset of the PACE study participants: PACE deidentified ECGpatch HRV dataset 28pts.xls

HRV indices measurement code V.1 Muammar Kabir, PhD, [email protected] Nichole Rogovoy, BS [email protected] Erick Andres Perez Alday, PhD, [email protected] Annabel Li-Pershing, BS, [email protected] Larisa Tereshchenko, MD, PhD, [email protected] Last update: August 13th, 2019

See pdf file in the repository for HRV Indices calculation methods.

See .m files in the repository for HRV parameters calculations.

Test files are provided for HRV calculation testing. Sampling rate 200 Hz. Amplitude resolution 4.88 µV.

• Rogovoy NM, Howell SJ, Lee TL, Hamilton C, Perez-Alday EA, Kabir MM, Zhang Y, Kim ED, Fitzpatrick J, Monroy-Trujillo JM, Estrella MM, Sozio SM, Jaar BG, Parekh RS, Tereshchenko LG. Hemodialysis Procedure-Associated Autonomic Imbalance and Cardiac Arrhythmias: Insights From Continuous 14-Day ECG Monitoring. J Am Heart Assoc. 2019 Oct;8(19):e013748. doi:10.1161/JAHA.119.013748. Epub 2019 Sep 28. PMID: 31564195; PMCID: PMC6806026. https://www.ncbi.nlm.nih.gov/pubmed/31564195
• BioRxiv preprint: doi: https://doi.org/10.1101/601542