This repository stores the code, presentations, and material used in the R-HTA in LMICs introductory 2023 tutorial. The following sections provide a breakdown of the primary documents and guidance on how to use them for your own personal training. The tutorial is based on several open-source frameworks for Cost-Effectiveness Analysis modelling in R, developed by the DARTH group, for HTA (see the citations section).

The R folder includes the core R script of the Markov model which produces the economic results for the cost-effectiveness analysis. The model is an R based replication of a model originally presented in chapter two of Decision Modelling for Health Economic Evaluation by Briggs A., et al.

The excel folder includes the original model's solution template, developed in Excel, provided by Oxford's Health Economics Research Centre (HERC).

The analysis folder includes the secondary R script that produces the economic analysis from the results of the Markov model.

• Install devtools to install darthtools, which is an R package from DARTH's GitHub. See below:

# Install release version from CRAN
install.packages("devtools")

# Or install development version from GitHub
# devtools::install_github("r-lib/devtools")

• then install darthtools using devtools

# Install development version from GitHub
devtools::install_github("DARTH-git/darthtools")

For syntax consistency, we follow the R syntax framework developed by the DARTH group:

• Alarid-Escudero F, Krijkamp EM, Pechlivanoglou P, Jalal HJ, Kao SYZ, Yang A, Enns EA. A Need for Change! A Coding Framework for Improving Transparency in Decision Modeling. PharmacoEconomics, 2190;37(11):1329--1339. https://doi.org/10.1007/s40273-019-00837-x

This tutorial is also based on several open-source R coding templates for HTA:

Alarid-Escudero F, Krijkamp EM, Enns EA, Yang A, Hunink MGM, Pechlivanoglou P, Jalal H. A Tutorial on Time-Dependent Cohort State-Transition Models in R using a Cost-Effectiveness Analysis Example (https://arxiv.org/abs/2108.13552). arXiv:2108.13552v2. 2022:1-37.

Alarid-Escudero F, Krijkamp EM, Pechlivanoglou P, Jalal H, Kao SZ, Yang A, Enns EA. A Need for Change! A Coding Framework for Improving Transparency in Decision Modeling. Pharmacoeconomics. 2019 Nov;37(11):1329-1339. doi: 10.1007/s40273-019-00837-x. PMID: 31549359; PMCID: PMC6871515 10.5281/zenodo.6620902. Last accessed 7 June 2022.

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