𝒫robabilistic modeling of RNA velocity ⬱

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Pyro-Velocity is a library for probabilistic inference in minimal models approximating gene expression dynamics from, possibly multimodal, single-cell sequencing data. It provides posterior estimates of gene expression parameters, predictive estimates of gene expression states, and local estimates of cell state transition probabilities. It can be used as a component in frameworks that attempt to retain the ability to propagate uncertainty in predicting: distributions over cell fates from subpopulations of cell states, response to cell state perturbations, or candidate genes or gene modules that correlate with determination of specific cell fates.

Please see the Documentation.

Changes for each release are listed in the Changelog.

Please review the Contributing Guide for instructions on setting up a development environment and submitting pull requests.

If you would like to apply Pyro-Velocity in your research, have an idea for a new feature, have a problem using the library, or just want to chat, please feel free to start a discussion.

If you have a feature request or issue using Pyro-Velocity that may require making changes to the contents of this repository, please file an issue containing

• a GitHub permananent link to the location in the repository you think is causing a problem or will require changes, and
• provide a minimal reproducible example of the problem or proposed improvement.

We are always interested in discussions and issues that can help to improve the Documentation.

AGPL