pharmacome / conso Goto Github PK

SET Evidence = "ABCC1: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]"

SET Subgraph = "Transport related subgraph"
p(HGNC:ABCC1) -| act(a(CHEBI:anticonvulsant))

# oxidized glutatione = glutathione disulfide
p(HGNC:ABCC1) -- tloc(a(CHEBI:"glutathione disulfide"))

# cysteinyl leukotrienes = leukotriene C4, D4, E4, F4
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene C(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene D(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene E(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"leukotriene F(4)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))
p(HGNC:ABCC1) -- tloc(a(CHEBI:"aflatoxin B(1)"), fromLoc(GOCC:"extracellular space"), toLoc(GOCC:"intracellular"))