This is an open-source python package for the extraction of Radiomics features from medical imaging.

With this package we aim to establish a reference standard for Radiomic Analysis, and provide a tested and maintained open-source platform for easy and reproducible Radiomic Feature extraction. By doing so, we hope to increase awareness of radiomic capabilities and expand the community.

The platform supports both the feature extraction in 2D and 3D. Not intended for clinical use.

If you publish any work which uses this package, please cite the following publication: Joost JM van Griethuysen, Andriy Fedorov, Chintan Parmar, Ahmed Hosny, Nicole Aucoin, Vivek Narayan, Regina GH Beets-Tan, Jean-Christophe Fillion-Robin, Steve Pieper, Hugo JWL Aerts, “Computational Radiomics System to Decode the Radiographic Phenotype”; Accepted Cancer Research 2017

Currently supports the following feature classes:

• First Order Statistics
• Shape-based
• Gray Level Cooccurence Matrix (GLCM)
• Gray Level Run Length Matrix (GLRLM)
• Gray Level Size Zone Matrix (GLSZM)

Aside from the feature classes, there are also some built-in optional filters:

• Laplacian of Gaussian (LoG, based on SimpleITK functionality)
• Wavelet (using the PyWavelets package)
• Square
• Square Root
• Logarithm
• Exponential

Aside from calculating features, the pyradiomics package includes provenance information in the output. This information contains information on used image and mask, as well as applied settings and filters, thereby enabling fully reproducible feature extraction.

For more information, see the sphinx generated documentation available here.

Alternatively, you can generate the documentation by checking out the master branch and running from the root directory:

python setup.py build_sphinx

The documentation can then be viewed in a browser by opening PACKAGE_ROOT\build\sphinx\html\index.html.

Furthermore, an instruction video is available here.

PyRadiomics is OS independent and compatible with both Python 2.7 and Python >=3.4. To install this package on unix like systems run the following commands from the root directory:

python -m pip install -r requirements.txt
python setup.py install

Detailed installation instructions, as well as instructions for installing PyRadiomics on Windows are available in the documentation.

PyRadiomics also supports Dockers. Currently, the only docker available is a Jupyter notebook with PyRadiomics pre-installed with example Notebooks. To build the Docker:

docker build -t radiomics/notebook .

The radiomics/notebook Docker has an exposed volume (/data) that can be mapped to the host system directory. For example, to mount the current directory:

docker run --rm -it --publish 8888:8888 -v `pwd`:/data radiomics/notebook

or for a less secure notebook, skip the randomly generated token

docker run --rm -it --publish 8888:8888 -v `pwd`:/data radiomics/notebook start-notebook.sh --NotebookApp.token=''

and open the local webpage at http://localhost:8888/ with the current directory at http://localhost:8888/tree/data.

PyRadiomics can be easily used in a Python script through the featureextractor module. Furthermore, PyRadiomics provides two commandline scripts, pyradiomics and pyradiomicsbatch, for single image extraction and batchprocessing, respectively. Finally, a convenient front-end interface is provided as the 'Radiomics' extension for 3D Slicer, available here.

• SimpleITK (Image loading and preprocessing)
• numpy (Feature calculation)
• PyWavelets (Wavelet filter)
• pykwalify (Enabling yaml parameters file checking)
• six (Python 3 Compatibility)

See also the requirements file.

• Implementation of this package as an extension to 3D Slicer

This package is covered by the open source 3-clause BSD License.

• Joost van Griethuysen^1,3,4
• Andriy Fedorov²
• Nicole Aucoin²
• Jean-Christophe Fillion-Robin⁵
• Ahmed Hosny¹
• Steve Pieper⁶
• Hugo Aerts (PI)^1,2

¹Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands, ⁴GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands, ⁵Kitware, ⁶Isomics

We are happy to help you with any questions. Please contact us on the pyradiomics email list.

We welcome contributions to PyRadiomics. Please read the contributing guidelines on how to contribute to PyRadiomics.

This work was supported in part by the US National Cancer Institute grant 5U24CA194354, QUANTITATIVE RADIOMICS SYSTEM DECODING THE TUMOR PHENOTYPE.