Solver status turning infeasible when trying to optimize about driven HOT 3 OPEN

Thank you for the detailed description. I will take a look at the zip that you provided. In general, nobody has worked on driven in a while so I wouldn't necessarily expect it to work out of the box.

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No problem, thank you for taking my problem into account. I know this probably does not make much sense but if the original metabolites are removed from the model (via remove_metabolites()) and only the "TM_" ones remain, the solver is able to find a solution.

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I've a similar issue coding a branch-and-price algorithm.
On model modification the exception 1225 is thrown, but changing some coefficients of the objective function creating the model avoid the error.
Unfortunately I need other values for that coefficients in the objective function.
So, it should not be a bug in my code.
I do not find any solution in the Cplex documentation.

I've asked a question with more details on stackoverflow: https://stackoverflow.com/questions/76627803/prevent-cplex-setting-to-nan-coefficients-of-problem-variables-exception-1225-i

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