Pregnant PBPK model of antipsychotic quetiapine.

Within this repository, we distribute a whole-body PBPK model of quetiapine for pregnant women. This work was conducted on a 27-compartment pregnancy model structure provided by Dallmann et al [1]. The detailed information on model development and evaluation was described in [2].

Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc...) is expected to follow the Open Systems Pharmacology code of conduct.

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

The model code is distributed under the GPLv2 License.

[1] Dallmann A, Ince I, Solodenko J, Meyer M, Willmann S, Eissing T, et al. Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women. Clin Pharmacokinet. 2017;56(12):1525-41.

[2] Zheng L, Tang SW, Tang R, Xu M, Jiang XH, Wang L. Dose Adjustment of Quetiapine and Aripiprazole for Pregnant Women Using Physiologically Based Pharmacokinetic Modeling and Simulation. Clin Pharmacokinet. 2020.