The following AEs do not seem to be included in OAE.
Karyorrhexis AE

The following terms are unclear for animal models.
Decreased activity AE - Different from exercise tolerance decreased AE or general physical health deterioration AE

Hi, would you please provide an OBO export of this ontology? Thanks!

This ontology contains several references to CTCAE, such as CTCAE:E12396, can you give some insight on what these xrefs are?

@e4ong1031 @yongqunh

This is the official OAE issue tracker site. You are welcome to submit any OAE-related issues.
Thanks, Oliver He

The OBO Foundry has recently created a topics page at https://github.com/topics/obofoundry. It would be great if you could add the obofoundry topic to your repository, since it's currently listed as active in the OBO Foundry. If you're not sure how to do that, follow the instructions here. The main issue for this task is at OBOFoundry/OBOFoundry.github.io#1538 in case you want some more context or to join the larger discussion.

Hi, while importing some terms from OAE into the eNM ontology we realized the class extravasation AE OAE_0000213 shares its label with its subclass OAE_0005475:

    <!-- http://purl.obolibrary.org/obo/OAE_0000213 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0000213">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OAE_0000546"/>
        <obo:IAO_0000115>an abnormal fluid regulation AE which has an outcome of extravasation, a discharge or escape, as of blood, from a vessel into the tissues.
</obo:IAO_0000115>
        <obo:IAO_0000117>YH, SS</obo:IAO_0000117>
        <obo:IAO_0000119>WEB: http://medical-dictionary.thefreedictionary.com/extravasation</obo:IAO_0000119>
        <obo:OAE_0004334 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10015866</obo:OAE_0004334>
        <rdfs:label>extravasation AE</rdfs:label>
    </owl:Class>

and

    <!-- http://purl.obolibrary.org/obo/OAE_0005475 -->

    <owl:Class rdf:about="http://purl.obolibrary.org/obo/OAE_0005475">
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/OAE_0000213"/>
        <obo:IAO_0000115>This is an AE which is the leakage of a fluid out of its container into the surrounding area, especially blood or blood cells from vessels.</obo:IAO_0000115>
        <obo:IAO_0000117>QY, JX, HY</obo:IAO_0000117>
        <obo:IAO_0000119>http://en.volupedia.org/wiki/Extravasation</obo:IAO_0000119>
        <obo:OAE_0001849>外渗</obo:OAE_0001849>
        <obo:OAE_0004334>10015866</obo:OAE_0004334>
        <rdfs:label>extravasation AE</rdfs:label>
    </owl:Class>

Is this a redundancy or are they supposed to be different terms?

Thanks!

<dc:description xml:lang="en">The Ontology of Adverse Eventsy (OAE) ...
contains a spelling mistake. Should be "Events" rather than "Eventsy".

I found that there's an AE in here called sandifer's syndrome AE (OAE:0009176) but there appears to be no connection to related sandifer's syndrome (MONDO:0019104)

Similarly, I was having trouble finding connections from OAE to related ontology terms, such as gastrointestinal disorder AE (OAE:0000455, which is the parent of sandifer's syndrome AE) to anything related to the gastrointestinal system (UBERON:0001007)

More generally, I guess my question is how can I use OAE as a hub of information? Right now, I can't seem to figure out what's the best way to use it

Hi, I am including the OWL file of the Ontology of Adverse Events (version 1.2.44) in a knowledge graph to investigate natural product-drug interactions and related adverse events from adverse event reports. I want to use the MedDRA and Human Phenotype Ontology mappings available in OAE to link the concepts in the knowledge graph and would like more information on the mappings, specifically -

• How were the mappings from MEDDRA concepts to OAE concepts created? Manually or by term matching? Also, are these mapped for MedDRA preferred terms or soc? E.g. cardiovascular AE (http://purl.obolibrary.org/obo/OAE_0000493) has_meddra_id 10007649 (meddra pt: cardiovascular disorder).
• How were the Human Phenotype Ontology (HPO) identifiers added in OAE? E.g. cardiovascular AE (http://purl.obolibrary.org/obo/OAE_0000493) seeAlso HPO: HP_0001626
• How recently were these mappings updated?

Thank you!