Compilation of human leukocyte antigen (HLA) alleles associated with immune responses to Small pox vaccines
The HLA alleles were manually curated from available literature sources and were systematically compiled in a pre-formatted template.
For extensive understanding on the prvealence of these alleles in various global populations, global allele frequencies were retrived from Allele Frequency Net Database (http://www.allelefrequencies.net/default.asp) and documented. Summary of HLA alleles with significant associations with Smallpox vaccine immune responses - HLA-A - 1
- HLA-B - 11
- HLA-DQB1 - 2
- HLA-DRB1 - 4
1. Ovsyannikova IG, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA. Human leukocyte antigen genotypes in the genetic control of adaptive immune responses to smallpox vaccine. J Infect Dis. 2011 Jun 1;203(11):1546-55. doi: 10.1093/infdis/jir167. PMID: 21592983; PMCID: PMC3096794.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096794/
2. Ovsyannikova IG, Pankratz VS, Salk HM, Kennedy RB, Poland GA. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. Hum Genet. 2014 Sep;133(9):1083-92. doi: 10.1007/s00439-014-1449-x. Epub 2014 Jun 1. PMID: 24880604; PMCID: PMC4127812.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127812/
3. DREXLER, I., STAIB, C., KASTENMÜLLER, W., STEVANOVIĆ, S., SCHMIDT, B., LEMONNIER, F. A., RAMMENSEE, H., BUSCH, D. H., BERNHARD, H., ERFLE, V. AND SUTTER, G.Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccineshttps://www.pnas.org/doi/abs/10.1073/pnas.262668999
4. Jun Ando, Minhtran C. Ngo, Miki Ando, Ann Leen, Cliona M. Rooney,Identification of protective T-cell antigens for smallpox vaccines,Cytotherapy,Volume 22, Issue 11,2020,Pages 642-652,ISSN 1465-3249https://www.sciencedirect.com/science/article/abs/pii/S1465324920306551?via%3Dihub
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