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estrogel-diy-guide-zh_cn's Issues

自制的凝胶似乎比爱思妥浓,是正常现象嘛?

如题,
在这个 test case 中,爱思妥的粘度比自制的小一些很多:
img8467776
在这个 test case 中,爱思妥还是纯洁的,但是自制的都拧麻花了,而且表面似乎有些颗粒物:
img8487342
img7943892

请问您们配置的凝胶也呈现这样的性状嘛,或是我的操作不规范?

待验证的原料供应商

Chinese Raw Suppliers - Google Docs
cas no50-28-2_cas编号查询_CPHI制药在线
β-雌二醇 CAS 50-28-2,β-雌二醇 [50-28-2]供应商大全-化工网

Checklist:

  • Be sure to complete a profile on the respective website. Look legit, upload basic information which indicates a small business operation rather than an individual. Companies may take you more seriously or shadier actors will be less likely to pray on your wallet. Particularly strict companies may even refuse service to individuals without a claim of conducting a legitmate business.

  • Pick a supplier and engage in a professional sounding email. You can quickly bring the conversation to Whatsapp or Wickr for convenience, but you should try and communicate through the wholesaler website chat services for transparency. Expect shitty translated correspondence but be mindful of how they sound: Too eager? Strange promises (free product next time, refunding shipping, etc.)? Rushing to close a deal? Too cheap? (this can be difficult as the entire purpose in Chinese sourcing is to massively cut costs)

  • Evaluate the source. Look at their personal website (which almost always look terrible but can have some clues), their wholesaler website profile page, accreditations by the sites, and time established. Cross reference this information with their personal company website.

  • If you choose, take advantage of the quality assurance systems some wholesaler sites offer. I know MadeInChina has a customer satisfaction escrow service (STS) which can be used for a minimal fee. This also allows you to gauge supposedly legitimate suppliers who may fold under the threat of enforcement of their product. This is not a requirement, however the topic during negotiations can give you information.

Some information on STS:
https://www.youtube.com/watch?v=c84B8RkYw2Q

  • Cross reference your source on https://www.supplierblacklist.com/.

  • Got scammed? There's sadly little that can be done unless you're a large business willing to track down a factory. The link above has some basic information which I'll summarize: Your embassy is too busy, local law enforcement doesn't care, and, from my experience, the aggregator sites don't give a shit about hard evidence against a company (at least MadeInChina).


1688上的原料真假存疑,见推文

Chinese Raw Suppliers - Google Docs,Hubei Vanz (湖北万知) 较为可信

关于雌二醇的纯度和真假?

我发现在电商平台明面上能买的的雌二醇原料最高只有98%的纯度(而且不一定可信),买不到99%医用级的了。
这种分析纯的化工原料雌二醇会不会对凝胶产生不利的影响?
有没有什么简单的方法可以粗略验证一下雌二醇的纯度以及,它到底是不是真的。纯度不够的话配比似乎还需要计算一下,当然也可以直接无脑过量(
如果雌二醇是假的那就彻底寄了(

如果气温过高,会导致溶液和成品的药效降低/失效吗?

一个月之前,我从去年年底开始制作的药物用完了,然后我开始重新制作新的药物,但是制作出来的药效非常低甚至可以说是失效(如果把整个大腿都涂满还是会有效果的,但不多)
这种时灵时不灵的药效让我很焦虑
目前试着换了两袋E2和烧杯,但是还是没有解决。在前面的问题里有看到真空瓶可能会漏气的问题所以现在准备等新真空瓶到了再试着做一瓶
我这里白天温度是33度左右,如果会被气温影响的话,那我是不是应该把酒精先放到冰箱里,然后等要制作的时候拿出来,做到卡波姆那一步的时候再放到冰箱里待卡波姆溶解完成呢?

使用结果

  • 爱思妥+螺内酯120mg
    将凝胶涂抹于蛋皮大腿内侧,每日一尺2.5克,使用一个月,9小时后雌二醇121pg/mL,睾酮0.5ng/mL,23小时雌二醇89pg/mL

  • 自制凝胶+螺内酯120mg
    配方:63mL无水乙醇,250mg雌二醇,37mL纯净水,1g氮酮,0.5g卡波姆980,0.65g三乙醇胺
    原配方基础上,卡波姆、三乙醇胺减半,成品质地接近爱思妥凝胶,加入1%水溶性氮酮作为促渗剂增加吸收
    使用结果:
    将凝胶涂抹于蛋皮大腿内侧,每日一次3克,使用半个月,12小时后雌二醇252pg/mL,睾酮0.12ng/mL,涂在另一只手采血点皮肤上雌二醇945pg/mL

  • 自制健民配方凝胶CN101036660A
    4倍浓度雌二醇,每日一次2.6克,使用3天,16h后E2=83pg/mL
    该配方含15%酒精,加水后雌二醇析出,吸收不好;卡波姆含量高,粘度大,晾干后成膜有胶皮

  • 贴片
    HEXAL Estramon 100μg,贴于小腹或臀部,两天半63h后E2=86pg/mL
    容易卷边脱落,不透气,贴3天后皮肤起红点比较痒;1月中旬贴了2片一周,没有过敏起红点,可能因为冬天出汗少

使用结果报告

使用频率:每次1.5mg,每日两次
使用部位:阴囊和大腿内侧
使用时长:1周
使用结果:
雌二醇:580 pg/mL
睾酮:2.23 ng/mL

根据文献,高剂量雌激素单药治疗需要4周左右才能完全发挥睾酮抑制作用,计划一个月后复查并上传结果。

用量应该怎么计算呢?

请问0.24的浓度是等于爱斯妥0.06浓度的4倍吗?比如我之前爱斯妥用3卡尺(7.5g),现在0.24浓度就是1.875g相当于爱斯妥的7.5g了吗?

买的雌太难溶了怎么办

我把雌加进75%的酒精里面,很久都不溶解,没法像图里那样5%的酒精里面,很久都不溶解,没法像图里那样做到无色透明,是不是买到假的了做到无色透明,是不是买到假的了

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