Mr.MtRobin: Multi-tissue transcriptome-wide Mendelian Randomization method ROBust to INvalid instrumental variables
The goal of Mr.MtRobin
is to provide tools to conduct transcriptome-wide Mendelian randomization analysis
using the MR-MtRobin algorithm. MR-MtRobin is a Multi-tissue transcriptome-wide Mendelian Randomization method ROBust
to INvalid instrumental variables that takes summary statistics from complex trait GWAS
and multi-tissue eQTL analyses as input and
uses a reverse regression random slope mixed model to infer whether a gene is
associated with a complex trait.
To install and load functions from Mr.MtRobin
, run the following:
devtools::install_github("kjgleason/Mr.MtRobin")
library("Mr.MtRobin")
To cite Mr.MtRobin
in publications, please use:
Kevin J. Gleason, Fan Yang and Lin S. Chen. A robust two-sample transcriptome-wide Mendelian randomization method integrating GWAS with multi-tissue eQTL summary statistics. Genet Epidemiol (2021); 45(4):353-371. doi:10.1002/gepi.22380.