The volcano3Ddata package provides the data to run examples in the volcano3D package. This enables exploration of probes differentially expressed between three groups. Its main purpose is for the visualisation of differentially expressed genes in a three-dimensional volcano plot. These plots can be converted to interactive visualisations using plotly.

These examples explore a case study from the PEAC rheumatoid arthritis trial (Pathobiology of Early Arthritis Cohort). The methodology has been published in ‘Lewis, Myles J., et al. “Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes.” Cell reports 28.9 (2019): 2455-2470.’ (DOI: 10.1016/j.celrep.2019.07.091) with an interactive web tool available at https://peac.hpc.qmul.ac.uk.

This tool acts as a searchable interface to examine relationships between individual synovial and blood gene transcript levels and histological, clinical, and radiographic parameters, and clinical response at 6 months. An interactive interface allows the gene module analysis to be explored for relationships between modules and clinical parameters. The PEAC interactive web tool was creating as an R Shiny app and deployed to the web using a server.

Not yet publicly available:

repos = getOption("repos")
repos["volcano3Ddata"] = "http://KatrionaGoldmann.github.io/volcano3Ddata"
options(repos = repos)

install.packages("volcano3Ddata")
library(volcano3Ddata)

volcano3D was developed by the bioinformatics team at the Experimental Medicine & Rheumatology department and Centre for Translational Bioinformatics at Queen Mary University London.

If you use this package please cite as:

Lewis, Myles J., et al. “Molecular portraits of early rheumatoid arthritis identify clinical and treatment response phenotypes.” Cell reports 28.9 (2019): 2455-2470.

or using:

citation("volcano3Ddata")

## 
## To cite package 'volcano3Ddata' in publications use:
## 
##   Katriona Goldmann and Myles Lewis (2020). volcano3Ddata: Data for
##   Interactive Plotting of Three-Way Differential Expression Analysis. R
##   package version 0.1.0.9000.
##   https://github.com/KatrionaGoldmann/volcano3D_data
## 
## A BibTeX entry for LaTeX users is
## 
##   @Manual{,
##     title = {volcano3Ddata: Data for Interactive Plotting of Three-Way Differential
## Expression Analysis},
##     author = {Katriona Goldmann and Myles Lewis},
##     year = {2020},
##     note = {R package version 0.1.0.9000},
##     url = {https://github.com/KatrionaGoldmann/volcano3D_data},
##   }