This repository describes ongoing work using Open Targets data to use mouse Knock outs models to inform human safety for Drug Discovery.
The most important use of mouse models for drug discovery could be summarize in the three next sections:
1. Disease Modeling:
- Mouse models replicate a wide range of human diseases.
- They aid in understanding disease mechanisms and identifying potential drug targets.
2. Safety and Toxicity Testing:
- Mice are crucial for assessing drug safety and potential toxicity.
- This step is vital for predicting human safety and optimizing drug dosages.
3. Efficacy Testing:
- Mouse models enable the evaluation of drug effectiveness prior to clinical trials.
- They reduce the risk of costly late-stage failures, ensuring the advancement of promising drug candidates.
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