Jian-Guo Zhou's Projects
A high-performance search engine for large-scale genomic interval datasets
An integrative database for investigating genetic model of drug response in cancer
š§¬ Immunarch by ImmunoMind: R Package for Fast and Painless Exploration of Single-cell and Bulk T-cell/Antibody Immune Repertoires
This repo contains the code necessary to reproduce the clusters found in "The Immune Landscape of Cancer".
Reproducible pipeline for "Comprehensive evaluation of cell-type quantification methods for immuno-oncology", Sturm et al. 2019, https://doi.org/10.1093/bioinformatics/btz363
A unified interface to immune deconvolution methods (CIBERSORT, EPIC, quanTIseq, TIMER, xCell, MCPcounter)
This resource provides the code developed in the study of Jerby-Arnon _et al. "Single-cell RNA-seq of melanoma ecosystems reveals sources of T cell exclusion linked to immunotherapy clinical outcomes".
Immunology-related bioinformatics data and tools
Immunology Informatics - Big Data Analysis in Immunology - Tutorials
Framework to process and call somatic variation from NGS dataset generated using MSK-IMPACT assay
ImReP is a computational method for rapid and accurate profiling of the adaptive immune repertoire from regular RNA-Seq data.
Ratio of the interferon-Ī³ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma
Inferring CNV from Single-Cell RNA-Seq
Intro to ChIPseq using HPC
IOBR is an R package to perform comprehensive analysis of tumor microenvironment and signatures for immuno-oncology.
This R package calculates various measures of association and helps understand and visualize the link between causal models such as Marginal Structural Models and Standerdized measures.
Machine learning-based integrative analysis develops an immune-derived lncRNA signature for improving clinical outcomes in colorectal cancer
Just a Microbiology System (JAMS) - a suite for analyzing microbiological sequencing data for use on NIH HPC systems (Biowulf)