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An example illustrating the extension of DLNMs for modelling exposure-lag-response associations beyond time series analysis. The code completely reproduces the examples and simulation study described in the article:

Gasparrini A. Modeling exposure–lag–response associations with distributed lag non-linear models. Statistics in Medicine. 2014;33(5):881-899. [freely available here]

This is complemented by the vignette dlnmExtended included in the R package dlnm, showing applications in alternative settings.

The code:

• uminers.csv stores the data from the Colorado Plateau uranium miners cohort, including individual information for 3,347 male subjects
• the numbered files from 00.prep.R to 08.simres.R reproduce the results of the illustrative example and of the simulation study
• example.R offers a simple example with of fitting some models and displaying/summarizing the results
• functions.R creates some functions used in the other scripts
• simprep.R and simrun.R are called from the other scripts for preparing and running the simulations

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