A memo for the development of novel CNV calling tools. To detect novel copy number variation events in plasma samples, here we develop a novel tool called ctCNV to help find such events.

Based on the read depth coverage of capture seqencing data, significance testing (EWT) algorithm will be used to found signicicantly altered CNV envents in case samples compared to a pool of normal control samples. The main python script is based on the improvement and application of CNVkit library (Thanks Eric Talevich! CNVkit on Github).