This is the accompanying code to paper "Sequential phase I dose-escalation trials with multiple schedules" by BK Günhan, S Weber, A Seroutou, and T Friede. We consider Everolimus trial to illustrate the use of our proposed method TITE-PK. See the paper for the details of the methodology.

TITE-PK (a time-to-event pharmacokinetic model) is a method for designing and analyzing phase I dose-escalation trials with multiple schedules, eg a daily and weekly dosing. Here, we consider sequential phase I trials involving multiple treatment schedules.

TITE-PK uses Stan via Rstan, hence it should be installed. See here for how to install it.

TITEPK_run.R is the main R-script which produce simulations described in the main text.

tite_pk.stan is the main Stan script which is used in TITEPK_run.R to simulate data and implement the TITE-PK model.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

The code was written by Burak Kürsad Günhan and Sebastian Weber. To report any issues or bugs or to suggest enhancements to the package, please go here.