KRS1 uses Kolmogorov-Zurbenko adaptive filtered [1] Fourier transform on structural alignments aiming to uncover distinct signatures. The software is currently in a highly experimental alpha phase. Example properties plotted in the frequency domain across an alignment include:

• amino acid mass
• amino acid volume
• average hydrophobicity
• phi and psi

Empty positions in an alignment (-) are currently represented as 0.0.

pip install -r requirements.txt

python main.py

*Requires an internet connection for initial Alphafold model download and phi psi angle calculation.

An interactive text UI will start to guide plot generation. To generate a plot, enter a column name/receptor name from the alignment file, ie. 'alignments/aminergic_alignment.txt' in the demo. Closing a plot will allow for generating the next plot.

1. https://wires.onlinelibrary.wiley.com/doi/10.1002/wics.71