All files for this submission are in this shared folder: https://drive.google.com/drive/folders/1Zsv4ictaT6eT1_Rb1NuKMMZFb7yOhu4x?usp=drive_link

My comments below are prefixed with Milton's comment:

Before submitting

Quotes from the email they sent and my comments:

• We require an additional point-by-point response to our editorial requests below. Please upload this using the file type ‘Related Manuscript File’ on our submission system, and do not modify or remove the previously uploaded cover letter or point-by-point response unless specifically asked.
  • Milton's comment: Responses are here (the document is in the shared folder).

Tasks

Crossed out text means the task is completed.

1. We noticed that your manuscript was submitted in a ZIP file. Please note that all material used in the compilation of your manuscript should be included within the source code for your article. If you wish to use BibTeX for references, please copy the reference list from the .bbl file, paste it into the main manuscript .tex file, and delete the associated \bibliography and \bibliographystyle commands.

   • Your article should comprise of a single LaTex file which contains all of the relevant code used in the compilation and you should confirm this file converts to PDF on your system before being sent to us. Whilst not extensive, there is some additional information on LaTex formatting on this page here: https://www.nature.com/ncomms/submit/how-to-submit. With this in mind, resubmit your Article File as a single LaTex file which contains all the relevant information for your manuscript.

   • Alternatively, you can submit your Article File as a Word Doc.

   • Milton's comment: I uploaded a file named manuscript-main_text.tex.

2. Please remove the author ORCIDs and social media handles (and logos) from the Article File.

3. Please reformat your author list using this paper as an example: https://www.nature.com/articles/s41467-020-16621-x.pdf.

4. Please make sure to include an address and country for each affiliation.

5. Blair Sullivan, Dr. Benjamin Voight, and Dr. Carsten Skarke appear to be missing from the Author Contributions section. Please ensure that each author of the manuscript is included here.

6. In the Author Contributions section, please use authors' initials instead of first initial and last names. For example, C.S.G., M.P., S.L., etc.

   • Milton's comment: There is a conflict with some author names, such as Carsten Skarke and Chun Su. I added this to the Response to Editorial requests document.

7. Thank you for uploading the BioRender.com license to publish document. Please be sure to include this attribution line "Created with BioRender.com" in the Figure 1 legend for panel a.

8. Please amend your references of "Supplementary File X" in the Article File to be "Supplementary Data X".

9. Since you have included the eMERGE consortium in your Author Contributions -- "W. Wei, Q. Feng, B. Namjou, K. Kiryluk, I. Kullo, Y. Luo, and M.D. Ritchie, as part of the eMERGE consortium, provided critical feedback regarding the analyses of this data." -- please be sure to follow our consortia guidelines:

   For papers containing one or more consortia, all members of the consortium who contributed to the paper must be listed in the paper. If necessary, individual authors can be listed in both the main author list and as a member of a consortium listed at the end of the paper. When submitting your revised manuscript, the consortium name should be entered as an author, together with the contact details of a nominated consortium representative. See http://www.nature.com/authors/policies/authorship.html for our authorship policy and https://www.nature.com/documents/nr-consortia-formatting.pdf for further consortia formatting guidelines, which should be adhered to prior to acceptance.

10. In Supplementary Figure 11, please remove the heading “Table 1”. We also encourage you to provide the primer sequences in a format that allows them to be extracted.

    • Milton's comment: I added Supplementary Data 8 with the primer sequences in readable format.

11. Tables (Table 1) must have a short title that summarises the whole table. Further details can be included as footnotes to the table.