To run the code, we suggest that users install Anaconda 3 in windows 10 and install the following necessary python packages with the same or higher version to set up a compatible environment: Python 3.7; Jupyter 1.0.0; numpy 1.20.2; pandas 1.3.0; scikit-learn: 0.22.1; matplotlib 3.4.2; shap 0.39.0; tensorflow-gpu 2.4.1; tensorflow-estimator 2.4.0; keras 2.4.3; keras-metrics 1.1.0; catboost 0.23.2; lightgbm 3.2.1; xgboost 1.0.2. For the .R scripts, please install the required packages illustrated in beginning of each script in the form of "library(xx)" interaction.R/measure_importance.R/min_depth_distribution.R/min_depth_interactions.R are scripts from DOI: 10.1126/sciadv.abf4130.