The graphical user interface and libraries of the FRET Positioning System Nature Methods in 2012.

FRET positioning refers to finding spatial positions and orientations of multiple structural subunits subject to a set of experimental FRET restraints. Each unit is assumed to have a known rigid structure. In addition to the restraints provided explicitly, clashes between subunits are taken into account. No other interactions (electrostatic, hydrophobic, ...) are considered. For comparable approaches see e.g. (Brunger et al, 2011) (also referred to as rigid body docking or rigid body MD).

FRET screening is a complementary method of "filtering" a structure library with respect to agreement with FRET data.

The original MS-Windows software (v1.1) can be found in the "release" folder. This version was wrapped for the use on MacOS (tested in High Sierra 10.13.4).

To install/use FPS simply download and unzip the following file and install a corresponding VC runtime for your Windows installation.

FPS-Windows

Windows x64

Windows x32

To use FPS on MacOS download and unzip the following archieve

FPS-MacOS

Additional information is available in FPS toolkit paper:

Kalinin, S., Peulen, T., Sindbert, S., Rothwell, P.J., Berger, S., Restle, T., Goody, R.S., Gohlke, H. and Seidel, C.A., 2012. A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nature methods, 9(12), pp.1218-1225.

Author(s): Stanislav Kalinin

Maintainer: tpeulen

License: LGPL This library is free software; you can redistribute it and/or modify it under the terms of the GNU Lesser General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version.