Comparing to the previous two main approaches, pure javascript implementation as well as traditional C implementation binding, using WebAssembly combines the pros from both sides, providing good performance while keeping best compatibility with modern Javascript runtime.

https://jameslan.github.io/libxml2-wasm/index.html

Due to the usage of WebAssembly, ES module and top level await etc, it requires the minimum version of the following environments,

Install libxml2-wasm package:

npm i libxml2-wasm

libxml2-wasm is an ES module, importing it are different between ES module and commonJS module.

Import it directly.

import fs from 'node:fs';
import { XmlDocument } from 'libxml2-wasm';
const doc1 = XmlDocument.fromString('<note><to>Tove</to></note>');
const doc2 = XmlDocument.fromBuffer(fs.readFileSync('doc.xml'));
doc1.dispose();
doc2.dispose();

Dynamic import is needed:

const fs = require('node:fs');
import('libxml2-wasm').then(({ XmlDocument }) => {
    const doc1 = XmlDocument.fromString('<note><to>Tove</to></note>');
    const doc2 = XmlDocument.fromBuffer(fs.readFileSync('doc.xml'));
    doc1.dispose();
    doc2.dispose();
});

IMPORTANT: dispose() is required to avoid memory leak.

For more detail, see the Doc.