Code for bi-directional MR analysis between m6A and epigenome (DNAme and H3K27ac) implemented by R package TwoSampleMR (v0.5.6). TwoSampleMR is available at https://mrcieu.github.io/TwoSampleMR.

Code for summary data-based Mendelian randomization (SMR) tests between m6A and epigenome implemented by the SMR software. SMR is avaliable at https://yanglab.westlake.edu.cn/software/smr.

Code for Bayesian-based colocalization analysis between m6A and epigenome implemented by R package coloc (v5.2.2). coloc is available at https://chr1swallace.github.io/coloc.

Code for multiple trait colocalization analysis among the two molecular layers (m6A and epigenome) and tissue-related GWAS datasets implemented by R package moloc (version 0.1.0). moloc is avaliable at https://github.com/clagiamba/moloc.

Code for cross-tissue effect sizes comparison, genomic distribution enrichment and regulators (RBPs and TFs) enrichment.