full vs aggregated data about biodosetools HOT 1 OPEN

My opinion is that as a general approach aggregated data is safer and sensitive to detect glm.disp , the use of 1/disp can mask the effect of sampling a poisson distribution detected by the glm.disp , however this modification change past published coeficients , more effort is needed to test the effect of sampling to few cells at higher doses 3 , 4 , 5 Gy . In general 60 to 80 cells for 5 Gy. I think that we need more influence of theses doses 500 to 300 cells scored to obtain a mean to get more influence on the beta parameter reducing the sampling error and varations between labs.

from biodosetools.