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SoBioS: Sobol' Indices for Biological Systems is an easy-to-run Matlab code used for Sobol' indices-based global sensitivity analysis of Biological Systems. The implementation follows an educational style, to make its use very intuitive.

This package includes the following modules:

• SoBioS_CaseName.m - main file for the simulation (use servaral resourses from UQLab package);
• QoI_CaseName.m - function to compute the Quantity of Interest (QoI).

This code was developed as a pedagogical tool to teach the basics of global sensitivity analysis of biological systems via Sobol' indices. A tutorial explaining the theory and practical aspects behind SoBioS package is provided in the following book chapter:

• Tosin M., Côrtes A.M.A., Cunha A. (2020) A Tutorial on Sobol’ Global Sensitivity Analysis Applied to Biological Models. In: da Silva F.A.B., Carels N., Trindade dos Santos M., Lopes F.J.P. (eds) Networks in Systems Biology: Applications for Disease Modeling. Computational Biology, vol 32. Springer, Cham https://doi.org/10.1007/978-3-030-51862-2_6

In order to use the SoBioS code, it is necessary to have UQLab package installed: https://www.uqlab.com

This external package is free for academic use.

• Michel Tosin
• Adriano Côrtes
• Americo Cunha

We kindly ask users to cite the following reference in any publications reporting work done with SoBioS:

• Tosin M., Côrtes A.M.A., Cunha A. (2020) A Tutorial on Sobol’ Global Sensitivity Analysis Applied to Biological Models. In: da Silva F.A.B., Carels N., Trindade dos Santos M., Lopes F.J.P. (eds) Networks in Systems Biology: Applications for Disease Modeling. Computational Biology, vol 32. Springer, Cham https://doi.org/10.1007/978-3-030-51862-2_6

@incollection{Tosin2020SoBioS,
   author    = {M. Tosin and A. M. A. C\ˆ{o}rtes and A. {Cunha~Jr}},
   title     = {A {T}utorial on {S}obol’ {G}lobal {S}ensitivity {A}nalysis {A}pplied to {B}iological {M}odels},
   editor    = {F.A.B. {da Silva} and N. Carels and M. {Trindade dos Santos} and F.J.P. Lopes},
   booktitle = {Networks in Systems Biology: Applications for Disease Modeling},
   publisher = {Springer International Publishing},
   address   = {Cham},
   year      = {2020},
   pages     = {93-118},
   doi       = {https://doi.org/10.1007/978-3-030-51862-2_6},
}

SoBioS is released under the MIT license. See the LICENSE file for details. All new contributions must be made under the MIT license.