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perishky (Matthew Suderman)

  • I am a Senior Lecturer in Epigenetic Epidemiology at the University of Bristol, UK.

  • Epigenetics is the study of mechanisms that determine biological charactistics independently of DNA sequence. Epigenetic mechanisms have critical roles in development and response to the environment.

  • Epidemiology is the study of health and disease in populations.

  • I create R packages and scripts for analysing DNA methylation datasets generated using the Illumina Infinium Beadchips, but have also created scripts for analysing data generated using other types of microarrays and high-througput sequencing.

    • The EWAS catalog is an online database of summary statistics of published epigenome-wide association studies.
    • meffil is for the quality assessment, normalization and analysis of genome-wide DNA methylation datasets.
    • ewaff is for testing associations in genome-wide DNA methylation datasets.
    • dmrff is for identifying differentially methylated regions.
    • meffonym is for calculating scores for a long list of DNA methylation models for estimating things like age and smoking history.
    • alspac is for querying the ALSPAC study data which is stored in SPSS and STATA formats.
  • I regularly produce an update of the Epigenetic Epidemiology literature 1-2 times per month.

  • I aim to write code that is as beautiful as perishky is tasty.

Matthew Suderman's Projects

dnamalci icon dnamalci

Easy estimation of DNA methylation alcohol (DNAm-Alcs) scores

journalclub icon journalclub

Uses citations and PubMed queries to generate new publications for a journal club.

meffil icon meffil

Efficient algorithms for analyzing DNA methylation data.

meffonym icon meffonym

R package for calculating indices of exposure and phenotype in DNA methylation datasets

methylseqextractor icon methylseqextractor

Tool for evaluating clonal DNA methylation concordance and heterogeneity in methyl-seq data

pc-clocks icon pc-clocks

Code for the calculation and implementation of the PC Based epigenetic clocks

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