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MicrobioSee avatar MicrobioSee commented on August 13, 2024

Do you get the answers? I also face your question.

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28rietd avatar 28rietd commented on August 13, 2024

Unfortunately the parameters used for the filtering are currently hard-coded in this file (L3-L5):

"""Hard-coded parameters for CNVkit. These should not change between runs."""

I would also be in favour of being able to change the default parameter settings.

In addition, would it also be possible to write the masked_bins to an output file instead of stdout, as now no output is returned if the list exceeds 500 bins?

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WortJohn avatar WortJohn commented on August 13, 2024

Thank you very much. It is a good idea for saving the filtered bins because the cluster signal maybe have very high log2ratio in itself. It may be a true amplification or deletion signal. If user can change the default parameter settings, cnvkit will be more perfect.

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