Comments (2)
Hi Matt,
There are a number of places a gradient can be supplied. Were you thinking for the FIM calculation, for improving gradient based search algorithms or something else?
Andy
from poped.
Thanks Andy,
Possibly for both. rxode2
calculates these for nlmixr2
focei and I thought they would be useful in both FIM calculation. I didn't see a hook so I didn't know if this was possible.
I was thinking of taking a nlmixr-style model and translating it to PopED, and was wondering if this would be useful and speed up the computation or increase the accuracy. This is currently mostly a development idea, but something I think may be useful.
Matt
from poped.
Related Issues (20)
- Manually updating the number of samples as an alternative to opt_samps in R? HOT 1
- Plotting optimized output seems to used wrong times HOT 1
- Where is the optimization parallelized HOT 3
- unused argument in plot_model_prediction() HOT 2
- parallel computation for plot_efficiency_of_windows() HOT 4
- problem with tests run by AppVeyor HOT 2
- Warning "Problems inverting the matrix. Results could be misleading." HOT 2
- Different results when running the optimization R-script in popED in Windows and Mac HOT 2
- Integrating an IV loading dose followed by SC maintenance dose using popEd HOT 1
- Illogical OFV when xts have a lot of significant digits HOT 2
- D-optimal Design for a trial comparing three different drugs
- Design Evaluation when No. of subjects change towards the end of trial HOT 6
- Handling derived outputs
- `evaluate_fim_map` documentation
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- Define a model with lag time HOT 5
- Take an example of the pk.3.comp.olal.ode model
- multiple dose full TMDD model in POPED HOT 3
- Two questions HOT 3
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